: Quest for Fire .

Quest for fire: seeking the source of pathogenic oxygen radicals in atherosclerosis.

There is an accumulating body evidence that atherosclerosis is either caused by or accompanied by oxidative events in the vessel wall. These oxidative events have been implicated in proatherogenic modification of proteins, alteration of gene expression, promotion of inflammation, remodeling of vessels, and perturbations of vascular tone. This body of literature has led to a dogma that oxidation...

FIRE AND ICE: The quest for the perfect modality in atrial fibrillation ablation

Atrial fibrillation (AF) is the most common arrhythmia in clinical practice. Catheter ablation of atrial fibrillation plays an important role in the management of AF. Radiofrequency ablation is widely used in practice all over the world. Cryoablation has emerged as an alternative method for AF ablation. The FIRE and ICE trial was a non inferiority, multicentre, randomized trial that compared be...

the quest for an hiv vaccine

The Quest for Uncertainty

The question of how to represent and process uncertainty is of fundamental importance to the scientific process, but also in everyday life. Currently there exist a lot of different calculi for managing uncertainty, each having its own advantages and disadvantages. Especially, almost all are defining the domain and structure of uncertainty values a priori, e.g., one real number, two real numbers...

Ongoing quest for QWERTY∗

First, we replicate the remarkable result of Hossain & Morgan (AER 2009), in which subjects in an experimental market tip almost perfectly to the superior platform even if an inferior platform enjoys initial monopoly. Next, we show that this result disappear when seemingly innocent increases in out-of-equilibrium payoffs are introduced. The inflated payoffs do not alter payoffor risk-dominance ...